Science

Deciphering the context-specific relationship between sequence and function is a major challenge in genomics. Existing tools for inducing locus-specific hypermutation and evolution in the native genome context are limited. Here we present a programmable … Source link

Gravity-driven sinking of “marine snow” sequesters carbon in the ocean, constituting a key biological pump that regulates Earth’s climate. A mechanistic understanding of this phenomenon is obscured by the biological richness of these aggregates and a … Source link

Epigenetic reinforcement of T cell exhaustion is known to be a major barrier limiting T cell responses during immunotherapy. However, the core epigenetic regulators restricting antitumor immunity during prolonged antigen exposure are not clear. We … Source link

How living systems achieve precision in form and function despite their intrinsic stochasticity is a fundamental yet ongoing question in biology. We generated morphomaps of preimplantation embryogenesis in mouse, rabbit, and monkey embryos, and these … Source link

Climate change is reducing winter ice cover on lakes; yet, the full societal and environmental consequences of this ice loss are poorly understood. The socioeconomic implications of declining ice include diminished access to ice-based cultural activities,… Source link

Between 2019 and 2023, 26 of the remaining 70 Javan rhinos were poached by two organized groups that have evaded authorities for years (1). In the first half of 2024, 229 South African rhinos were poached for their horns (2), destined for illegal markets as traditional medicine or status symbols. These incidents, driven by the

In September 2023, more than 11,000 people died after torrential rainfall triggered the collapse of two dams in Libya (1). In May 2024, a flash flood in Mashhad, Iran, led to loss of lives because of poorly designed and malfunctioning stormwater drainage systems (2). Developing nations will increasingly confront similar hazards as their aging water

In June, the US Supreme Court overturned a 40-yearold legal principle known as the Chevron doctrine, which deferred to federal agencies on how regulations are interpreted in legal cases when the legislation enacted by Congress is unclear. Striking a blow … Source link

HomeScienceVol. 386, No. 6718Strong stuffBack To Vol. 386, No. 6718 Full accessFeatureGraphene Share on Strong stuffMark PeplowAuthors Info & AffiliationsScience10 Oct 2024Vol 386, Issue 6718p. 143DOI: 10.1126/science.adt7439 PREVIOUS ARTICLEComing of agePreviousNEXT ARTICLEGraphene, beyond lab benchesNext NotificationsBookmark ContentsInformation & AuthorsMetrics & CitationsView OptionsReferenc… Source link

The first era of genomics started with the publication of Watson and Crick’s notable work on the description of the DNA double helix in 1953. This era lasted 50 years, until the publication of the human genome in April 2003. The second era is associated … Source link