Science

Decades of research on the infamous antinutritional steroidal glycoalkaloids (SGAs) in Solanaceae plants have provided deep insights into their metabolism and roles. However, engineering SGAs in heterologous hosts has remained a challenge. We discovered … Source link

Deciphering the complex interplay between neuronal activity and mitochondrial function is pivotal in understanding brain aging, a multifaceted process marked by declines in synaptic function and mitochondrial performance. Here, we identified an age-… Source link

The global diversity of Proterozoic eukaryote fossils is poorly quantified despite its fundamental importance to the understanding of macroevolutionary patterns and dynamics on the early Earth. Here we report a new construction of fossil eukaryote … Source link

Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein complex function can be modulated by RNA molecules that … Source link

HomeScienceVol. 386, No. 6728Conflict drives mpox epidemic in eastern DRCBack To Vol. 386, No. 6728 Full accessLetter Share on Conflict drives mpox epidemic in eastern DRCMisaki Wayengera [email protected]Authors Info & AffiliationsScience19 Dec 2024Vol 386, Issue 6728p. 1356DOI: 10.1126/science.adt3171 PREVIOUS ARTICLEBecoming Roger PenrosePreviousNEXT ARTICLEFDA should consider drug-therapy reg… Source link

In his In Depth story “What’s next for psychedelics after MDMA rejection?” (16 August, p. 702), K. Kupferschmidt describes how the US Food & Drug Administration (FDA) turned down the application of a combination of 3,4-methylenedioxymethamphetamine (MDMA), also known as ecstasy, and psychotherapy for posttraumatic stress disorder, in part because the regimen involves both a

Viral surveillance is crucial to detecting isolated disease outbreaks and preventing them from growing into epidemics or pandemics. Gaps in disease surveillance contributed to the 2020 COVID pandemic (1) and the 2014 Ebola outbreak (2). Because viruses know no borders, US viral surveillance relies on sending reagents, which are used to detect the presence of

Next year will mark the 100th anniversary of the Scopes trial, a 1925 court case in the US state of Tennessee on the teaching of evolution in public schools. John Scopes was tried for violating the Butler Act, a state rule that declared unlawful any … Source link

Collective phenomena arise from interactions within complex systems, leading to behaviors absent in individual components. Observing quantum collective phenomena with macroscopic mechanical oscillators has been impeded by the stringent requirement that … Source link

St. Ives is an idyllic seaside town on the southwest tip of England. It is a magnet for holidaymakers and artists. In early 2023, its residents were surprised to find that their beloved bay had become the location for an experiment. A technology start-up … Source link