Science

Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens with in vitro–transcribed mRNAs in lipid … Source link

Light-sheet fluorescence microscopy has revolutionized biology by visualizing dynamic cellular processes in three dimensions. However, light scattering in thick tissue and photobleaching of fluorescent reporters limit this method to studying thin or … Source link

Human high-order thalamic nuclei activity is known to closely correlate with conscious states. However, it is not clear how those thalamic nuclei and thalamocortical interactions directly contribute to the transient process of human conscious perception. … Source link

Microbial life has dominated Earth’s history but left a sparse fossil record, greatly hindering our understanding of evolution in deep time. However, bacterial metabolism has left signatures in the geochemical record, most conspicuously the Great … Source link

Insects dominate animal species diversity yet face many threats from anthropogenic drivers of change. Many features of insect ecology make them a challenging group, and the fragmented state of knowledge compromises our ability to make general statements … Source link

Living cells that produce biofuel; robots that assist factory workers; intelligent machines that guide drug discovery—these technologies are “deep” in that they achieve something extraordinary—often thought impossible—and push society forward. Indeed, so-… Source link

HomeScienceVol. 388, No. 6742Science safeguardsBack To Vol. 388, No. 6742 Full accessLetterNextGen Voices Share on Science safeguardsZhen Wang [email protected], Sara Shakir [email protected], […] , Bram Servais [email protected], Safaa Osman [email protected], […] , Yutong Hu [email protected], Yumna Gamal [email protected], Malk Elshrief [email protected], Karen Jacqueline Cloete [email pro… Source link

The artificial intelligence (AI) debate is increasingly polarized in Africa, mirroring a trend across the globe. On one side, utopian headlines, such as “5 Ways To Harness AI And End Poverty Forever,” claim that AI will revolutionize development. On the … Source link

Hedonic eating is defined as food consumption driven by palatability without physiological need. However, neural control of palatable food intake is poorly understood. We discovered that hedonic eating is controlled by a neural pathway from the peri–… Source link

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic datasets, we identified lysosomal leucine aminopeptidase (… Source link